Hey I will give my anecdotal recent experience. Several months ago I switched to Pop! OS and have had basically no issues. I have an Nvidia GPU and I play a lot of games. I don’t play any games that are blocked by anti cheat (not because I can’t, I just don’t happen to play the few that are blocked).
I spent the first day getting everything signed in, installed, set up and tweaked to how I like it with very minimal terminal usage. Mostly gui and clicking.
Steam+Proton along with lutris makes it easy to play any game for me.
Side note: I have 4 monitors of varying resolution, size, orientation and refresh rate and it hasn’t caused problems other than the initial setup (I used cursr to help with this)
One monitor will be fine no matter the resolution.