

It depends on the instance. I created an account on mastodon with guerillamail which would be even more suspicious for an average website than your alias email. A tip, if you do not mind using icloud email, you can even create one with some effort without giving real personal data and using apple hardware (Virtual machines ftw), you can take advantage of its free alias email addresses which would be accepted even on most strict websites.
It already blocks me from reading access for some time because of VPN. I have to use libreddit on the web or redreader on mobile to access. This made me lurk reddit less, never had an account there anyway.