Nope everything usually just works, wine-mono takes care of .NET stuff. Take a look at the optional dependencies for wine (archlinux example), many of those lib32 libraries may be needed.
Cutting edge game-specific fixes that are not yet on normal system wine (especially for a stable distribution with an older wine package) might be on wine-ge that you can install from Lutris, and optionally use for a game or set as the default runner for all new games.
“App uses a third party service for currency exchange rates” (source: f-droid app or the metadata repo)
Nothing to do with it being a launcher