Sounds like it’d work great. You might want to use something like DigitalOcean instead of your home machine, for a couple different reasons. DigitalOcean is cheap for this type of application (like on the order of, IDK, $5-10 a month or something).

Also, fair warning, the current generation of Fediverse software is a pain in the ass to install, even before you get into issues of upgrading it, staying on top of security of the server, etc etc. But sure, it’s doable if you’re savvy and willing to invest some small time into it.

Lemmy often racks up hundreds of gigabytes in logs and other crap, chokes up the hard drive, and then force restarts the server. Not fun for something you use to stream media from. Takes quite some tuning to get it sorted.

If we are talking about two virtual machines on the same physical server with dedicated storage allocation, that shouldn’t matter.

There’s no context to the question?

At face value, no, there’s no technical reason you can’t run a Plex server and a lemmy instance on one computer :)

U can probably use docker and pass through a large storage volume